Limbic System 2

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What are the primary efferent connections of the limbic system? The ANS, somatic motor systems, and pituitary hormone release.  
What is the efferent connection through the ANS? The hypothalamus, via the pituitary gland, feeding, fight or flight, and reproduction.  
Where do the motor responses from the somatic motor systems originate? Not the primary motor cortex but the prefrontal and supplementary motor cortex, descend to the RAS.  
What will be the effect of an orbitofrontal the lesion of the limbic association cortex? Blunted affect, minimal emotional response to pain, decreased motivation, cognitive perseveration, but IQ is usually intact.  
What is the effect of a frontal lobe lobotomy? Flat affect, bilateral removal leads to motor restlessness and insomnia.  
What is the effect of an inferior temporal lobe lesion (temporal pole and hippocampus)? Inability to learn a visual task, cannot process information.  
What is the effect of a lesion in the hippocampus ? If bilateral, will not be able to put current events into long term memory, past memory is still intact.  
What is the effect of a lesion in the amygdala? Flat affect, hypersexuality, disinhibited behavior, socially embarrassing.  
Describe Kluver-Bucy syndrome. Bilateral lesions of the temporal lobe involving amygdala and hippocampal formation, results in visual agnosias, hyperorality, hypersexuality, flat affect, apathetic.  
What is the effect of a lesion on the basal ganglia? This is where movements are expressed with emotions, part of the limbic association circuitry.  
Where is the site for schizophrenia In the limbic subcortical structures of the basal ganglia.  
What is the effect of a lesion in the septal nuclei? Anorexia, gluttony, bulemia.  
What is the effect of a lesion in the thalamus? Thalamus provides our emotional responses to sensations, Korsakoff’s syndrome.  
Describe Korsakoff’s syndrome. Results from alcoholism, malnutrition, vitamin B1 deficiency (destroys thalamic nuclei and mammillary bodies), anterograde and retrograde amnesia and confabulation.  
What is the effect of a lesion in the hypothalamus? Anorexia, bulimia, bizarre attack behaviors/violence .  

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